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1986年美国达拉斯市，恐同的德州电工罗恩·伍德鲁夫（马修·麦康纳 Matthew McConaughey 饰）发现自己患上“同志病”——艾滋，生命只剩30天。他使用的AZT（叠氮胸苷）是当时美国药管局唯一批准面市的抗艾药物，但毒性极大。为了活下去，罗恩开始研究各种抗艾处方和替代疗法，甚至走私来自世界各地未经批准的药物。在医生萨克斯（詹妮弗·加纳 Jennifer Garner 饰）和异装癖同性恋雷蒙（杰瑞德·莱托 Jared Leto 饰）的帮助下，罗恩开始成立了一个叫做“达拉斯买家俱乐部”的地下组织，为艾滋病人提供更多“非常规疗法”，很多患病的男女同性恋亦求助于他。他的举动自然受到了药管局和药商的阻挠和施压。罗恩最终在1992年9月去世，离他被告知只剩30天可活已经过去了2557天。在这近7年时间里，他坚持不懈的与病魔、与药管局及制药商进行艰苦的斗争，享受真正活过的人生...... 本片根据真人真事改编，讲述一个绝症病人如何努力求生并拯救成千上万面临同样境遇的人的故事，提名金球奖剧情类最佳男主/男配以及获得大小29个奖项。
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