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Trata sobre la vida de un hospital de Nueva York a principios del siglo XX y narra las innovaciones científicas llevadas a cabo y las relaciones laborales y humanas entre sus empleados. La historia está basada en el Knickerbocker Hospital de Nueva York, que se fundó en 1862 y que cerró sus puertas en 1979. Uno de sus protagonistas, John Thackery, se inspira en la figura de William Stewart Halsted, un innovador médico de principios de siglo.
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