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I 'Sherlock Holmes' bliver mesterdetektiven (Robert Downey Jr.) og hans pålidelige kollega Watson (Jude Law) stillet overfor nogle store udfordringer.Holmes afslører, at hans kampevner er lige så farlige som hans legendariske intellekt, og han må kæmpe som aldrig før for at fange en ny fjende og for at opklare et dødbringende plot, som kan ødelægge hele landet.Makkerparret er oppe imod den mystiske modstander, Blackwood (Mark Strong), men kan måske få hjælp fra Irene Adler (Rachel McAdams), den eneste kvinde der nogensinde har overvundet Holmes og som har fastholdt et stormfuldt forhold til detektiven.Med 'Sherlock Holmes' genfortolker Guy Ritchie ('Lock, Stock and Two Smoking Barrels', 'Snatch') Arthur Conan Doyles legendariske karakter.
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