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Vad håller ihop en familj? Nick Cassavetes, regissören till "Dagboken" och "John Q", visar återigen sin känsla för berättelser om djupa mänskliga relationer i denna inspirerande film om en kärleksfull familj - utmanad och förenad - av ett barns sjukdom. Cameron Diaz, Abigail Breslin, Alec Baldwin mfl skapar en fantastisk känsla i berättelsen om 11-åriga Anna Fitzgerald, född för att vara donator till sin leukemidrabbade äldre syster, men som till slut kräver rätt att bestämma över sin egen kropp.
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