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Основният персонаж е стажантката по хирургия Мередит Грей. Тя се опитва да се пребори с несправедливостта на живота с помощтта на своята най-добра приятелка Кристина Янг, както и другите стажанти Джордж О'Мали, Изабел (Изи) Стивънс и Алекс Карев. Техен наставник е наричаната "нацистът" - Миранда Бейли. В основата на сериала стои любовната история между Мередит и един от лекарите в болницата "Сиатъл Грейс" - Дерек Шепърд.
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