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Serien begynder tre år efter, at en zombie-virus har hærget USA og udslettet det meste af befolkningen.
Her skal et et hold af transportere den eneste kendte overlevende af sygdommen, Murphy (Keith Allan) fra New York til Californien, hvor det sidste fungerende blodlaboratorium venter på at undersøge hans blod.
Selv om de antistoffer, han har i kroppen, er det bedste håb om at få skabt en vaccine som kan kurrere den frygtede ZN1 virus, gemmer Murphy på en mørk hemmelighed, der truer dem alle.
Med menneskehedens overlevelse på spil begiver den ulige flok sig ud på en rejse tværs hen over et post-apokalyptisk Amerika.
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