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Aus einer Zukunft, in der eine Pandemie die Welt heimgesucht und die menschliche Zivilisation ausgelöscht hat, wird der Zeitreisende Cole in die Zeit vor der Apokalypse entsandt, um dort die Ursache der Katastrophe zu finden und zu eliminieren. In unserer Gegenwart sucht er die Hilfe der brillanten Medizinerin Cassandra Railly. Doch sie muss zunächst eine Entscheidung darüber treffen, ob sie Coles Geschichte Glauben schenken und ihm bei der Aufdeckung einer Verschwörung helfen möchte.
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