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Patrick Melrose (Benedict Cumberbatch) es un aristócrata inglés que lucha por vencer sus demonios internos y superar sus problemas con el alcohol, derivados de una infancia complicada con un padre terriblemente estricto (Hugo Weaving) y una madre (Jennifer Jason Leigh) que, como él, bebía demasiado. Cada episodio, dedicado a cada una de las cinco novelas de Edward St. Aubyn, está escrito para televisión por el nominado al BAFTA David Nicholls ("Lejos del mundanal ruido", "One Day") y dirigido por Edward Berger ("Deutchland 83", "Jack"). Una saga que comienza en el sur de Francia en la década de 1960, continúa en el Nueva York de la década de 1980 y acaba en Gran Bretaña a principios de la década de los 2000.
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