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A finales del siglo XXI, surge una subcultura de seres humanos con una mutación genética: están dotados de una asombrosa velocidad, una increíble resistencia y una profunda inteligencia. A medida que hay más personas contagiadas, el temor del gobierno aumenta y a los mutantes se les trata como a marginados, se les somete a pruebas espantosas y se les pone en cuarentena. El gobierno ha tomado la determinación de acabar con ellos, pero una mujer está decidida a impedirlo: la ultrabella y ultraletal Violet (Milla Jovovich). Gracias a sus impresionantes técnicas de artes marciales y a su capacidad camaleónica, Violet se convierte en una guerrera solitaria dedicada a proteger a su nueva raza y a vengarse de los que la crearon.
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