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Pour une raison inconnue, les humains de partout à travers le globe sont victimes d'attaques violentes de la part des animaux. Au Botswana, le biologiste américain Jackson Oz est témoin d'une violente attaque de lions et sauve Chloé Tousignant, un agent des services secrets français. Pendant ce temps à Los Angeles, la journaliste Jamie Campbell tente de faire tomber Reiden Global, une puissante compagnie de biotechnologie aux méthodes douteuses… Un spécialiste du comportement animalier est mandaté pour stopper cette pandémie mondiale mystérieuse… Arrivera-t-il à sauver l’humanité?
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