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Il Danvers State Mental Hospital, vecchio manicomio chiuso da 15 anni, sta per ricevere cinque nuovi visitatori. Gordon (Peter Mullan), proprietario della Hazmat Elimination Co, ha vinto l'appalto per la rimozione dell'amianto dall'ospedale, prossimo alla ristrutturazione. Della sua squadra fanno parte Bill (Paul Guilfoyle), tecnico responsabile, il caposquadra Phil (David Caruso), Mike (Stephen Gevedon), l'ansioso Hank (Josh Lucas) e Jeff (Brendan Sexton III), nipote di Gordon. I cinque uomini si avventurano nei reparti immensi e vuoti dell'ospedale dove regna un'atmosfera inquietante... Oscuri segreti sembrano trapelare dalle corsie ormai deserte, portando alla luce orribili verità.
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