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Claire Simmons (Jennifer Aniston) é uma mulher traumatizada e depressiva, que busca ajuda em um grupo para pessoas com dores crônicas. Lá, ela descobre o suicídio de um dos membros do grupo, Nina (Anna Kendrick). Claire fica obcecada pela história desta mulher, e começa a investigar a sua vida. Aos poucos, começa a desenvolver uma relação inesperada com o ex-marido de Nina, Roy (Sam Worthington).
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