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Skupinka aktivistů, která bojuje za práva zvířat, vtrhne do laboratoře, kde vědci zkoumají opice infikované vzteklinou. Rozjetí ochránci opice pustí z klecí ven a ty je okamžitě pokoušou a nakazí. O 28 dní později se pracovník kurýrní služby Jim probudí v nemocnici z kómatu a zjistí, že budova zeje prázdnotou. Zděšený a osamělý mladý muž opustí nemocnici, aby objevil celou hrůzu. Londýn se naprosto vylidnil. Někde jsou vidět umírající. Virus zlikvidoval téměř celé město.
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