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Det er i et desperat forsøg på at fikse livet, at Annie Landsberg og Owen Milgrim vælger at lægge krop og sind til et mystisk medicinsk forsøg, der skal løse alle deres problemer. Ifølge medicinalfirmaet har behandlingen hverken komplikationer eller bivirkninger, men forsøget går galt, og to de hovedpersoner ender med at befinde sig i et mentalt mellemstadie, hvor virkelighed og fantasi blandes på kryds og tværs, og gør det umuligt for dem at kende forskel.
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