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Die junge Journalistin Anne Roland folgt der mysteriösen Spur ihres verschwundenen Freundes James Hirsch, der mit der von der Regierung während des Kalten Krieges verwendeten Droge MK-Ultra experimentiert hat. Auf der Suche nach James bekommt sie selbst bald die Langzeitwirkung der halluzinogenen Droge zu spüren.
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