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Η ιστορία εστιάζει στον Yorick Brown, τον τελευταίο άνδρα επιζών στη Γη, ύστερα από μια επιδημία που εξαφάνισε όλα τα θηλαστικά με το χρωμόσωμα Υ. Ο Yorick θα ταξιδέψει σε όλο τον κόσμο με τον Ampersand, την αρσενική μαϊμού-κατοικίδιο που επίσης επέζησε της επιδημίας και με την βοήθεια της γιατρού Allison Mann και της πράκτορος Agent 355, θα προσπαθήσουν να ανακαλύψουν το 'κλειδί' που θα βοηθήσει στην επιβίωση της ανθρωπότητας.
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