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Tras la inesperada muerte de su padre, Alan (Zach Galifianakas) es llevado por sus amigos Phil (Bradley Cooper), Stu (Ed Helms) y Doug (Justin Bartha) a un centro especializado para que mejore. Esta vez no hay boda ni fiesta de despedida ¿Qué puede ir mal? Pues que cuando estos chicos salen a la carretera, y sobre todo cuando aparece Chow (Ken Jeong)... la suerte está echada. Tercera entrega de la franquicia iniciada en 2009 con 'Resacón en Las Vegas'.
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