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Dos mujeres muy diferentes, una estadounidense (Hilary Swank) y otra inglesa (Brenda Blethyn), forman un estrecho vínculo cuando sus hijos mueren en África por causa de la malaria. Fortalecidas por su amistad, forman una alianza que las lleva desde su encuentro en una remota parte de Mozambique hasta Washington, donde estas dos madres comunes y corrientes hacen algo extraordinario.
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