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A bord de la barca que capitaneja Frank Wolff, viatgen la científica britànica Lily Houghton i el seu germà MacGregor. S’endinsen en la selva amb l’objectiu de trobar “l'arbre de la vida” per les seves llegendàries propietats curatives que han de transformar la medicina moderna per sempre. A més d’un clima asfixiant, també hauran de fer front a animals salvatges i a la competència d’una expedició alemanya que no escatimarà recursos per fer-los fracassar en la seva missió.
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