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影片根据1993年同名射击游戏改编而成。 2145年火星舰队总部接到从该地区传来的微弱求救信号,而在那里科学探测站正在进行着遗传密码破解的重要实验,一旦该地区失去控制,无疑将会造成整个人类的一场大劫难。特别行动队队长瑞博尔(卡尔·厄本 Karl Urban 饰)、士官长萨吉(道恩·强森 Dwayne Johnson 饰)带着六名队员迅速登陆以救援基地内的幸存者,可当他们进入基地时,发现实验室不仅一片狼藉,而且实验室里满是怪物。更可怕的是,这些行为怪异的生物并非来自外星,而是受到某种未知病毒感染后的人类!面对随时可能被感染的危险,萨吉必须和他的队员们利用手中的每一件武器,深入到实验室中心,找出真相,完成他们的使命。RRTSRTS惟一可以做的是把通往地球的通道用免疫隔离系统封锁,再背水一战,用尽身上每一件终极武器,将这班魔怪一一歼灭……
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