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电视台女主播安吉拉(珍妮弗•卡彭特 Jennifer Carpenter 饰)第一次出镜有些紧张,因为她要参加一个在洛杉矶某消防局与队员共度夜晚的节目。安吉拉性格热情开朗,所以逐渐融入了这个团队,她不但了解了每个人的个性,而且还迅速成为了他们的开心果。然而,突然接到911的报警电话,安吉拉随这群消防队员来到了出事地点。在这座阴森可怖的大楼里,不时传出女人凄厉的尖叫,当地警方已经封锁了大楼,消防队员试图疏散被困人群,却无意中身陷困境。在隔离的区域,一个女人不知感染什么病毒,残忍地伤害了许多人。眼看着消防队员惨遭不幸,自身难保的安吉拉被逼上了绝路……
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